NDLI: Prevention of graft-versus-host disease by anti–IL-7Rα antibody

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Prevention of graft-versus-host disease by anti–IL-7Rα antibody

Content Provider	Scilit
Author	Chung, Brile Dudl, Eric P. Min, Dullei Barsky, Lora Smiley, Nancy Weinberg, Kenneth I.
Copyright Year	2007
Description	Graft-versus-host disease (GVHD) continues to be a serious complication that limits the success of allogeneic bone marrow transplantation (BMT). Using IL-7–deficient murine models, we have previously shown that IL-7 is necessary for the pathogenesis of GVHD. In the present study, we determined whether GVHD could be prevented by antibody-mediated blockade of IL-7 receptor α (IL-7Rα) signaling. C57/BL6 (H2Kb) recipient mice were lethally irradiated and underwent cotransplantation with T-cell–depleted (TCD) BM and lymph node (LN) cells from allogeneic BALB/c (H2Kd) donor mice. Following transplantation, the allogeneic BMT recipients were injected weekly with either anti–IL-7Rα antibody (100 μg per mouse per week) or PBS for 4 weeks. Anti–IL-7Rα antibody treatment significantly decreased GVHD-related morbidity and mortality compared with placebo (30% to 80%). IL-7Rα blockade resulted in the reduction of donor CD4+ or CD8+ T cells in the periphery by day 30 after transplantation. Paradoxically, the inhibition of GVHD by anti–IL-7Rα antibody treatment resulted in improved long-term thymic and immune function. Blockade of IL-7R by anti–IL-7Rα antibody resulted in elimination of alloreactive T cells, prevention of GVHD, and improvement of donor T-cell reconstitution.
Related Links	http://www.bloodjournal.org/content/bloodjournal/110/8/2803.full.pdf
Ending Page	2810
Page Count	8
Starting Page	2803
DOI	10.1182/blood-2006-11-055673
Journal	Blood
Issue Number	8
Volume Number	110
Language	English
Publisher	American Society of Hematology
Publisher Date	2007-10-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Antibody Allogeneic Gvhd Bone Marrow Transplantation Prevention Bmt Mice Journal: Blood (Vol- 105, Issue- 8)
Content Type	Text
Resource Type	Article

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