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Iron overload in the Asian community
| Content Provider | Scilit |
|---|---|
| Author | Lok, Chun Yu Merryweather-Clarke, Alison T. Viprakasit, Vip Chinthammitr, Yingyong Srichairatanakool, Somdet Limwongse, Chanin Oleesky, David Robins, Anthony J. Hudson, John Wai, Phyu Premawardhena, Anuja de Silva, H. Janaka Dassanayake, Anuradha McKeown, Carole Jackson, Maurice Gama, Rousseau Khan, Nasaim Newman, William Banait, Gurvinder Chilton, Andrew Wilson-Morkeh, Isaac Weatherall, David J. Robson, Kathryn J. H. |
| Copyright Year | 2009 |
| Description | Hereditary hemochromatosis is an iron overload disorder that can lead to the impairment of multiple organs and is caused by mutations in one or more different genes. Type 1 hemochromatosis is the most common form of the disease and results from mutations in the HFE gene. Juvenile hemochromatosis (JH) is the most severe form, usually caused by mutations in hemojuvelin (HJV) or hepcidin (HAMP). The autosomal dominant form of the disease, type 4, is due to mutations in the SLC40A1 gene, which encodes for ferroportin (FPN). Hereditary hemochromatosis is commonly found in populations of European origin. By contrast, hemochromatosis in Asia is rare and less well understood and can be masked by the presence of iron deficiency and secondary iron overload from thalassemia. Here, we provide a comprehensive report of hemochromatosis in a group of patients of Asian origin. We have identified novel mutations in HJV, HAMP, and SLC40A1 in countries not normally associated with hereditary hemochromatosis (Pakistan, Bangladesh, Sri Lanka, and Thailand). Our family studies show a high degree of consanguinity, highlighting the increased risk of iron overload in many countries of the developing world and in countries in which there are large immigrant populations from these regions. |
| Related Links | http://www.bloodjournal.org/content/114/1/20.full.pdf |
| Ending Page | 25 |
| Page Count | 6 |
| Starting Page | 20 |
| DOI | 10.1182/blood-2009-01-199109 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 114 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2009-07-02 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Hereditary Hemochromatosis Iron Overload Asian Hamp Slc40a1 Hjv Journal: Blood (Vol- 20, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
