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Nontransferrin-bound iron in plasma from hemochromatosis patients: effect of phlebotomy therapy
| Content Provider | Scilit |
|---|---|
| Author | Aruoma, Oi Bomford, A. Polson, Rj Halliwell, B. |
| Copyright Year | 1988 |
| Description | Plasma from patients with iron overload resulting from idiopathic hemochromatosis contains nontransferrin-bound iron, measurable by the bleomycin, assay. During venesection therapy, the concentration of bleomycin iron declines in a way highly correlated with plasma ferritin concentrations. Even when patients had been venesected to give very low total plasma iron concentrations and high transferrin iron-binding capacity, bleomycin-detectable iron was still present at low concentrations. Bleomycin-detectable iron can stimulate damaging free radical reactions, and its persistence in plasma even after prolonged venesection might contribute to the tissue damage that results from iron overload. |
| Related Links | https://ashpublications.org/blood/article-pdf/72/4/1416/598905/1416.pdf |
| Ending Page | 1419 |
| Page Count | 4 |
| Starting Page | 1416 |
| DOI | 10.1182/blood.v72.4.1416.1416 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-10-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Iron Overload Plasma Bleomycin Concentrations Venesection Bound Hemochromatosis Detectable Nontransferrin Journal: Blood (Vol- 76, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |
