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Chronic Granulocytic Leukemia Complicated by Ulcerative Colitis: Elevated Leukocyte Alkaline Phosphatase and Possible Modifier Gene Deletion
| Content Provider | Scilit |
|---|---|
| Author | Rosen, M. D. Robert B. Teplitz, M. D. Raymond L. |
| Copyright Year | 1965 |
| Description | A boy with Ph1-positive chronic granulocytic leukemia and coincidental active ulcerative colitis presented with high leukocyte alkaline phosphatase (LAP) scores. Recession of the inflammatory process was accompanied by a marked fall of enzyme activity to expected levels for chronic granulocytic leukemia. The extreme variations of LAP under these and related circumstances appear inconsistent with a simple gene-dose hypothesis as applied to the partial deletion of chromosome 21. A system of control based on studies of bacterial enzyme synthesis and involving sequential repression by a pair of regulatory genes on chromosome 21 is proposed. Loss of a regulator (modifier) rather than the structural gene for LAP is offered as being in closer accord with the known behavior of this enzyme in chronic granulocytic leukemia. |
| Related Links | https://ashpublications.org/blood/article-pdf/26/2/148/572098/148.pdf |
| Ending Page | 156 |
| Page Count | 9 |
| Starting Page | 148 |
| DOI | 10.1182/blood.v26.2.148.148 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 26 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1965-08-01 |
| Access Restriction | Open |
| Subject Keyword | Colitis Leukocyte Phosphatase Extreme Chromosome Ulcerative Chronic Granulocytic Granulocytic Leukemia Journal: Blood (Vol- 44, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
