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G-6-PD Manchester: A New Variant Associated With Chronic Nonspherocytic Hemolytic Anemia
Content Provider | Scilit |
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Author | Milner, B. M. Gillian Delamore, Irvine W. Yoshida, M. D. Akira |
Copyright Year | 1974 |
Description | A variant of glucose-6-phosphate dehydrogenase (G-6-PD) designated G-6-PD Manchester, and associated with chronic nonspherocytic hemolytic anemia, was found in an English male. The electrophoretic mobility at pH 7.0 of this G-6-PD variant is the slowest yet described. Substrate specificity is normal but enzyme activity is markedly inhibited by NADPH, and this is thought to account for the severe chronic hemolysis. |
Related Links | https://ashpublications.org/blood/article-pdf/43/2/271/578086/271.pdf |
Ending Page | 276 |
Page Count | 6 |
Starting Page | 271 |
DOI | 10.1182/blood.v43.2.271.271 |
Journal | Blood |
Issue Number | 2 |
Volume Number | 43 |
Language | English |
Publisher | American Society of Hematology |
Publisher Date | 1974-02-01 |
Access Restriction | Open |
Subject Keyword | Medical Laboratory Technology Male Hemolysis Hemolytic Electrophoretic Nonspherocytic Markedly Pd Manchester Journal: Blood (Vol- 46, Issue- 2) |
Content Type | Text |
Resource Type | Article |