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Platelet-melanoma cell interaction is mediated by the glycoprotein IIb- IIIa complex
| Content Provider | Scilit |
|---|---|
| Author | Boukerche, H. Berthier-Vergnes, O. Tabone, E. Dore, Jf Leung, Ll McGregor, Jl |
| Copyright Year | 1989 |
| Description | A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions and platelet-platelet aggregation. M3Dau melanoma cells bind LYP 18 and synthesize IIb-IIIa- like GPs. When the melanoma cells were preincubated with LYP 18, tumor- platelet interaction did not occur, suggesting that the interaction may be mediated by the IIb-IIIa-like GPs present on the melanoma cell surface. Glanzmann's thrombasthenic platelets, lacking GPIIb and IIIa, did not interact with melanoma cells, indicating that the platelet GPIIb-IIIa complex is also necessary for the platelet-melanoma cell interaction. This work demonstrates the importance of the IIb-IIIa-like GPs, present on M3Dau melanoma cells, in mediating tumor-platelet interactions. |
| Related Links | https://ashpublications.org/blood/article-pdf/74/2/658/218522/658.pdf |
| Ending Page | 663 |
| Page Count | 6 |
| Starting Page | 658 |
| DOI | 10.1182/blood.v74.2.658.bloodjournal742658 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 74 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1989-08-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Antibody Platelet Glycoprotein Gpiib Iib Iiia Melanoma Cell Iiia Complex Journal: Blood (Vol- 54, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
