NDLI: Transcription patterning of uncoupled proliferation and differentiation in myelodysplastic bone marrow with erythroid-focused arrays

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Transcription patterning of uncoupled proliferation and differentiation in myelodysplastic bone marrow with erythroid-focused arrays

Content Provider	Scilit
Author	Lee, Y. Terry Miller, Lance Gubin, Alexander N. Makhlouf, Fairouz Wojda, Urszula Barrett, A. John Liu, Edison T. Miller, Jeffery L.
Copyright Year	2001
Description	Because abnormal erythroid differentiation is the most common manifestation of the myelodysplastic syndromes (MDS), it was hypothesized that erythroid gene expression may be used to illustrate myelodysplastic transcription patterns. Ten normal bone marrow aspirates (NBM) were first analyzed using an erythroid-focused cDNA array to define steady-state transcription levels. Proliferation and differentiation gene subsets were identified by statistically significant differences between NBM and erythroleukemia gene expression. Next, cDNAs from 5 separate MDS aspirates were studied: refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (RAEB-T), and RAEB-T/secondary MDS. A distinct pattern of significantly increased proliferation-associated and reduced differentiation-associated gene activity was established for MDS.
Related Links	http://www.bloodjournal.org/content/bloodjournal/98/6/1914.full.pdf
Ending Page	1921
Page Count	8
Starting Page	1914
DOI	10.1182/blood.v98.6.1914
Journal	Blood
Issue Number	6
Volume Number	98
Language	English
Publisher	American Society of Hematology
Publisher Date	2001-09-15
Access Restriction	Open
Subject Keyword	Hematology Differentiation Gene Expression Bone Marrow Refractory Anemia Proliferation Cdna Erythroid Raeb Blasts Journal: Blood (Vol- 90, Issue- 6)
Content Type	Text
Resource Type	Article

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