NDLI: The beta subunit of the interleukin-2 receptor mediates interleukin-2 induction of anti-CD3 redirected cytotoxic capability in large granular lymphocytes

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The beta subunit of the interleukin-2 receptor mediates interleukin-2 induction of anti-CD3 redirected cytotoxic capability in large granular lymphocytes

Content Provider	Scilit
Author	Colamonici, Or Quinones, R. Rosolen, A. Trepel, Jb Sausville, E. Phares, Jc Gress, R. Poplack, D. Weber, J. Schechter, Gp
Copyright Year	1988
Description	The interleukin 2 (IL 2) receptor was studied in three cases of large granular lymphocyte (LGL) lymphocytosis. All cases were nonreactive with anti-Tac monoclonal antibody (MoAb; recognizing the p55 alpha subunit of the IL 2 receptor). Sodium dodecyl sulfate (SDS)/polyacrylamide gel electrophoretic analysis (PAGE) of cells to which radio-labeled rIL 2 had been chemically crosslinked revealed uniform expression of the p70/75 beta subunit of the IL 2 receptor in the absence of the alpha subunit. Stimulation of this receptor with 2 nmol/L rIL 2 for five days led to acquisition of anti-CD3 redirected cytotoxicity. This was accompanied by a fivefold to tenfold elevation in the activity of intracellular N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl esterase, an LGL granule marker enzyme. These effects of IL 2 did not require induction of the Tac peptide.
Related Links	https://ashpublications.org/blood/article-pdf/71/3/825/366110/825.pdf
Ending Page	828
Page Count	4
Starting Page	825
DOI	10.1182/blood.v71.3.825.bloodjournal713825
Journal	Blood
Issue Number	3
Volume Number	71
Language	English
Publisher	American Society of Hematology
Publisher Date	1988-03-01
Access Restriction	Open
Subject Keyword	Antibody Sodium Lgl Anti Cd3 Redirected Cd3 Redirected Cytotoxicity Journal: Blood (Vol- 67, Issue- 3)
Content Type	Text
Resource Type	Article

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