NDLI: Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

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Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

Content Provider	Scilit
Author	Almeida, Jorge R. Sauce, Delphine Price, David A. Papagno, Laura Shin, So Youn Moris, Arnaud Larsen, Martin Pancino, Gianfranco Douek, Daniel C. Autran, Brigitte Sáez-Cirión, Asier Appay, Victor
Copyright Year	2009
Description	CD8+ T cells are major players in the immune response against HIV. However, recent failures in the development of T cell–based vaccines against HIV-1 have emphasized the need to reassess our basic knowledge of T cell–mediated efficacy. CD8+ T cells from HIV-1–infected patients with slow disease progression exhibit potent polyfunctionality and HIV-suppressive activity, yet the factors that unify these properties are incompletely understood. We performed a detailed study of the interplay between T-cell functional attributes using a bank of HIV-specific CD8+ T-cell clones isolated in vitro; this approach enabled us to overcome inherent difficulties related to the in vivo heterogeneity of T-cell populations and address the underlying determinants that synthesize the qualities required for antiviral efficacy. Conclusions were supported by ex vivo analysis of HIV-specific CD8+ T cells from infected donors. We report that attributes of CD8+ T-cell efficacy against HIV are linked at the level of antigen sensitivity. Highly sensitive CD8+ T cells display polyfunctional profiles and potent HIV-suppressive activity. These data provide new insights into the mechanisms underlying CD8+ T-cell efficacy against HIV, and indicate that vaccine strategies should focus on the induction of HIV-specific T cells with high levels of antigen sensitivity to elicit potent antiviral efficacy.
Related Links	https://ashpublications.org/blood/article-pdf/113/25/6351/1310793/zh802509006351.pdf
Ending Page	6360
Page Count	10
Starting Page	6351
DOI	10.1182/blood-2009-02-206557
Journal	Blood
Issue Number	25
Volume Number	113
Language	English
Publisher	American Society of Hematology
Publisher Date	2009-06-18
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Antigen Efficacy Vaccine Cd8 Antiviral Hiv Suppressive Activity Journal: Blood (Vol- 2007, Issue- 25)
Content Type	Text
Resource Type	Article

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