NDLI: Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia

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Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia

Content Provider	Scilit
Author	Loughran, Tp Jr Starkebaum, G. Aprile, Ja
Copyright Year	1988
Description	Ten patients with large granular lymphocyte (LGL) leukemia were studied for rearrangement and expression of T cell receptor (TCR) genes. Eight patients with CD3+ LGL proliferation had unique TCR beta-gene rearrangements, supporting a clonal process. Each of five patients studied with CD3+ disease had evidence for expression of full-length TCR alpha-, beta-, and gamma-gene transcripts. In contrast, patients with CD3- LGL proliferation had no evidence for rearrangement or expression of TCR genes. These studies suggest that leukemic LGL arise from two different cell origins. Leukemic LGL may be a useful model for studying natural killer (NK) cell (CD3- LGL) and non-MHC-restricted cytotoxic T lymphocyte (CD3+ LGL) activation and differentiation.
Related Links	https://ashpublications.org/blood/article-pdf/71/3/822/366102/822.pdf
Ending Page	824
Page Count	3
Starting Page	822
DOI	10.1182/blood.v71.3.822.bloodjournal713822
Journal	Blood
Issue Number	3
Volume Number	71
Language	English
Publisher	American Society of Hematology
Publisher Date	1988-03-01
Access Restriction	Open
Subject Keyword	Hematology Differentiation Tcr Leukemia Beta Lymphocyte Cd3 Granular Leukemic Rearrangement and Expression Journal: Blood (Vol- 67, Issue- 3)
Content Type	Text
Resource Type	Article

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