Loading...
Please wait, while we are loading the content...
Similar Documents
Rearrangement and expression of T cell antigen receptor genes in B cell chronic lymphocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Norton, Jd Pattinson, J. Hoffbrand, Av Jani, H. Yaxley, Jc Leber, Bf |
| Copyright Year | 1988 |
| Description | Fifty-nine patients with B cell chronic lymphocytic leukemia (B-CLL) were screened for clonal rearrangement of T cell receptor (TCR) beta and gamma chain genes. Four were found with rearranged TCR beta genes, but none had detectable rearrangement of TCR gamma genes. One typical patient with B-CLL had a TCR beta gene structure consistent with a variable-diversity-joining rearrangement into the C beta 2 gene on one allele. An apparently identical rearrangement pattern was seen in a second patient, which suggested that there may be a restriction on the repertoire of possible TCR beta gene recombinations in mature B cells. Two further patients had a simple deletion of sequences, consistent with a diversity-joining rearrangement into C beta 2 on one allele. All four patients had rearrangements of immunoglobulin heavy- and light- chain genes typical of mature B cell malignancies. However, on review of clinical, morphological, and immunophenotype data, two had features consistent with B cell prolymphocytic leukemia or B lymphoma, and a third had progressed to a prolymphocytic transformation. Low-level expression of a predominantly 1.0- to 1.2-kilobase germ line TCR beta gene transcript was detected in several B-CLLs and at a comparable level in the four with rearranged TCR beta genes. This, together with the low frequency of TCR gene rearrangement, suggests that most B-CLL cases arise at a developmental stage when factors required for TCR gene activity are not operative. |
| Related Links | https://ashpublications.org/blood/article-pdf/71/1/178/365909/178.pdf |
| Ending Page | 185 |
| Page Count | 8 |
| Starting Page | 178 |
| DOI | 10.1182/blood.v71.1.178.bloodjournal711178 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 71 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-01-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Diversity Rearrangement Leukemia Antigen Rearranged Tcr Tcr Beta Gene Journal: Blood (Vol- 4, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
