NDLI: Study of Langerhans cells after allogeneic bone marrow transplantation

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Study of Langerhans cells after allogeneic bone marrow transplantation

Content Provider	Scilit
Author	Perreault, C. Pelletier, M. Landry, D. Gyger, M.
Copyright Year	1984
Description	We assessed the number of Langerhans cells (LC) before and after bone marrow transplantation (BMT) in 27 patients in order to study the fate and behavior of these dendritic antigen-presenting cells following allogeneic BMT. LC were identified using monoclonal antibody OKT6 on skin biopsies performed on days - 10, 0, 11, 25, 39, 120, and 365. In a control group composed of 15 healthy adults aged 20–37 yr, the mean number of LC (+/- SEM) was 25.6 +/- 1.17/0.1 sq mm of epidermal surface. Our study shows that pretransplant, the number of LC in patients with aplastic anemia or leukemia was lower than that of controls. The finding of low numbers of LC in patients with untreated aplastic anemia is suggestive of a medullary origin of LC in man. Moreover, during the early posttransplant period, nearly all patients present a severe deficit in LC. This deficit may delay the maturation of their immune system. The number of LC reaches nearly normal levels 4– 12 mo after BMT. Finally, we have noted a significant impairment of LC reconstitution in patients with acute graft-versus-host disease (GVHD), providing evidence that this defect may be an important mechanism involved in acute GVHD-related immunodeficiency.
Related Links	https://ashpublications.org/blood/article-pdf/63/4/807/591257/807.pdf
Ending Page	811
Page Count	5
Starting Page	807
DOI	10.1182/blood.v63.4.807.807
Journal	Blood
Issue Number	4
Volume Number	63
Language	English
Publisher	American Society of Hematology
Publisher Date	1984-04-01
Access Restriction	Open
Subject Keyword	Allergy Research and Experimental Medicine Behavior Antibody Bone Marrow Gvhd Allogeneic Antigen Bmt Langerhans Aplastic Journal: Blood (Vol- 75, Issue- 4)
Content Type	Text
Resource Type	Article

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