NDLI: How I treat CMV reactivation after allogeneic hematopoietic stem cell transplantation

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How I treat CMV reactivation after allogeneic hematopoietic stem cell transplantation

Content Provider	Scilit
Author	Einsele, Hermann Ljungman, Per T. Boeckh, Michael J.
Copyright Year	2020
Description	Cytomegalovirus (CMV) reactivation remains one of the most common and life-threatening infectious complications following allogeneic hematopoietic stem cell transplantation, despite novel diagnostic technologies, several novel prophylactic agents, and further improvements in preemptive therapy and treatment of established CMV disease. Treatment decisions for CMV reactivation are becoming increasingly difficult and must take into account whether the patient has received antiviral prophylaxis, the patient’s individual risk profile for CMV disease, CMV-specific T-cell reconstitution, CMV viral load, and the potential drug resistance detected at the time of initiation of antiviral therapy. Thus, we increasingly use personalized treatment strategies for the recipient of an allograft with CMV reactivation based on prior use of anti-CMV prophylaxis, viral load, the assessment of CMV-specific T-cell immunity, and the molecular assessment of resistance to antiviral drugs.
Related Links	https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2019000956/1720001/blood.2019000956.pdf
Ending Page	1629
Page Count	11
Starting Page	1619
DOI	10.1182/blood.2019000956
Journal	Blood
Issue Number	19
Volume Number	135
Language	English
Publisher	American Society of Hematology
Publisher Date	2020-05-07
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Treatment Hematopoietic Prophylaxis Antiviral Viral Load Stem Transplantation Allogeneic Cmv Reactivation Journal: Blood (Vol- 131, Issue- 19)
Content Type	Text
Resource Type	Article

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