NDLI: How I treat measurable (minimal) residual disease in acute leukemia after allogeneic hematopoietic cell transplantation

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How I treat measurable (minimal) residual disease in acute leukemia after allogeneic hematopoietic cell transplantation

Content Provider	Scilit
Author	Spyridonidis, Alexandros
Copyright Year	2020
Description	Although allogeneic hematopoietic cell transplantation (allo-HCT) is currently the standard curative treatment of acute leukemia, relapse remains unacceptably high. Measurable (minimal) residual disease (MRD) after allo-HCT may be used as a predictor of impending relapse and should be part of routine follow-up for transplanted patients. Patients with MRD may respond to therapies aiming to unleash or enhance the graft-versus-leukemia effect. However, evidence-based recommendations on how to best implement MRD testing and MRD-directed therapy after allo-HCT are lacking. Here, I describe our institutional approach to MRD monitoring for preemptive MRD-triggered intervention, using patient scenarios to illustrate the discussion.
Related Links	https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2019003566/1558017/blood.2019003566.pdf
Ending Page	1649
Page Count	11
Starting Page	1639
DOI	10.1182/blood.2019003566
Journal	Blood
Issue Number	19
Volume Number	135
Language	English
Publisher	American Society of Hematology
Publisher Date	2020-05-07
Access Restriction	Open
Subject Keyword	Hematology Treatment Hematopoietic Transplantation Allogeneic Leukemia Relapse Residual Hct Mrd Journal: Blood (Vol- 131, Issue- 19)
Content Type	Text
Resource Type	Article

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