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Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation. BGMT Group
| Content Provider | Scilit |
|---|---|
| Author | Attal, M. Blaise, D. Marit, G. Payen, C. Michallet, M. Vernant, Jp Sauvage, C. Troussard, X. Nedellec, G. Pico, J. |
| Copyright Year | 1995 |
| Description | A prospective, randomized trial was initiated in adult acute lymphoblastic leukemia (ALL) to compare (1) disease-free survival (DFS) after allogeneic or autologous bone marrow transplantation (BMT) and (2) the relapse rate of patients treated with or without interleukin-2 (IL-2) after autologous BMT. A total of 135 previously untreated patients, aged under 55 years, received the Berlin-Frankfurt-Muster (BFM) induction regimen: 126 patients (93%), of which 120 were HLA- typed, achieved complete remission (CR). According to this genetic randomization, patients with (n = 43) or without an HLA-identical sibling (n = 77) were to receive allogeneic or autologous BMT, respectively. The 3-year post-CR probability of DFS was significantly higher in the HLA-identical sibling group than in the non-HLA-identical sibling group (68% v 26%; P < .001). Eligible patients were randomized to receive (n = 30) or not to receive (n = 30) IL-2 after autologous BMT: the 3-year post-BMT probability of continuous CR was similar in both groups (29% v 27%, respectively). We conclude that, in ALL, early allogeneic BMT after the BFM induction regimen is an effective consolidation treatment and that IL-2 does not decrease the high relapse rate observed after autologous BMT. |
| Related Links | https://ashpublications.org/blood/article-pdf/86/4/1619/617434/1619.pdf |
| Ending Page | 1628 |
| Page Count | 10 |
| Starting Page | 1619 |
| DOI | 10.1182/blood.v86.4.1619.bloodjournal8641619 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 86 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1995-08-15 |
| Access Restriction | Open |
| Subject Keyword | Hematology Treatment Survival Bone Marrow Transplantation Adult Allogeneic Leukemia Autologous Sibling Lymphoblastic Journal: Blood (Vol- 77, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |
