NDLI: Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia

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Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia

Content Provider	Scilit
Author	Robinson, N. Sanders, Je Benyunes, Mc Beach, K. Lindgren, C. Thompson, Ja Appelbaum, Fr Fefer, A.
Copyright Year	1996
Description	Allogeneic bone marrow transplantation (BMT) for advanced acute leukemia is associated with a high risk of relapse. It is postulated that interleukin-2 (IL-2) administered after BMT might induce or amplify a graft-versus-leukemia effect and thereby reduce the relapse rate. To identify an IL-2 regimen for testing this hypothesis, a phase I trial of IL-2 (Roche) was performed in children in complete remission (CR) without active graft-versus-host disease (GVHD) off immunosuppressive agents after unmodified allogeneic matched-sibling BMT for acute leukemia beyond first remission. Beginning a median of 68 days after BMT, 17 patients received escalating doses of induction IL-2 (0.9, 3.0, or 6.0 x 10(6) IU/m2/d representing levels I, II, and III) for 5 days by continuous intravenous infusion (CIV). After 6 days of rest, they received maintenance IL-2 (0.9 x 10(6) IU/m2/d) for 10 days by CIV infusion. Levels I and II were well-tolerated, but, of 6 patients at level III, 1 developed pulmonary infiltrates, 1 developed hypotension (both resolved), and 1 died of bacterial sepsis and acute respiratory distress syndrome. Grade II acute GVHD developed in 1 patient at level I and 1 at level III. The maximum tolerated dose of induction IL-2 was level II. IL-2 induced lymphocytosis, with an increase in CD56+ and CD8+ cells. Ten patients remain in CR at 5+ to 67+ months. Thus, a regimen of IL-2 has been identified that did not induce a high incidence of acute GVHD when administered to children after unmodified allogeneic BMT. Its clinical activity will be assessed in a phase II trial.
Related Links	https://ashpublications.org/blood/article-pdf/87/4/1249/620226/1249.pdf
Ending Page	1254
Page Count	6
Starting Page	1249
DOI	10.1182/blood.v87.4.1249.bloodjournal8741249
Journal	Blood
Issue Number	4
Volume Number	87
Language	English
Publisher	American Society of Hematology
Publisher Date	1996-02-15
Access Restriction	Open
Subject Keyword	Hematology Children Bone Marrow Gvhd Allogeneic Leukemia Acute Bmt Iii Tolerated Unmodified Journal: Blood (Vol- 77, Issue- 4)
Content Type	Text
Resource Type	Article

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