NDLI: Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia

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Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia

Content Provider	Scilit
Author	Roth, Ms Antin, Jh Bingham, El Ginsburg, D.
Copyright Year	1989
Description	Sixteen patients treated by allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr/abl-specific RNA transcripts at various time points after BMT. In reconstitution experiments, one CML cell per million normal mononuclear cells could be detected by direct agarose gel visualization of a bcr/abl-specific band following PCR. Bcr/abl message was found in ten out of 16 patients post-BMT. PCR- positive bcr/abl was present only transiently in three patients and correlated with relapse in three. One patient died in clinical remission, while two patients remain in remission despite persistence of bcr/abl-positive abl-positive cells at 180 days. Long-term follow-up of bcr/abl-positive patients in clinical remission may provide insight into the fate or residual Ph+ cells after BMT. This approach may aid in the identification of high-risk patients likely to relapse post-BMT.
Related Links	https://ashpublications.org/blood/article-pdf/74/2/882/601813/882.pdf
Ending Page	885
Page Count	4
Starting Page	882
DOI	10.1182/blood.v74.2.882.882
Journal	Blood
Issue Number	2
Volume Number	74
Language	English
Publisher	American Society of Hematology
Publisher Date	1989-08-01
Access Restriction	Open
Subject Keyword	Hematology Bone Marrow Transplantation Leukemia Remission Chain Cml Bmt Bcr/abl Myelogenous Positive Cells Journal: Blood (Vol- 54, Issue- 2)
Content Type	Text
Resource Type	Article

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