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Prognostic significance of immunoglobulin phenotype in B cell chronic lymphocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Baldini, L. Mozzana, R. Cortelezzi, A. Neri, A. Radaelli, F. Cesana, B. Maiolo, At Polli, Ee |
| Copyright Year | 1985 |
| Description | Seventy-six consecutive untreated patients with B cell chronic lymphocytic leukemia (B-CLL) and classified according to Binet's staging system were studied at the clinical presentation. Several immunologic parameters (number of total and T circulating lymphocytes and their surface membrane immunoglobulin [Smlg] phenotypes and levels of serum Ig) were evaluated with the aim of identifying a biologic marker of prognostic relevance. In this series of persons, Binet staging confirmed its usefulness as a prognostic index (P less than .001). With regard to Smlg, they were mu-type in 41 cases (53.9%), mu- type plus delta-type in 29 cases (38.2%), alpha-type in one case, and not detectable in five cases. No correlations were found between clinical stage and immunoglobulin phenotype, although all but one patient in stage C showed mu-type Smlg alone. On analyzing the survival curves of our patients according to different Smlg phenotypes, we found that patients with only mu-type Smlg had a poorer prognosis (P less than .05) than those with mu-type plus delta-type; this difference was even more significant (P less than .01) in patients in stage A, whereas there were no statistical differences in those in stages B and C. Because the appearance of surface heavy chain of delta-type could be an expression of cell maturation, these results suggest that in B-CLL the presence of phenotypically more mature leukemic cells may correlate with better clinical prognosis, particularly in the early phase of the disease. |
| Related Links | https://ashpublications.org/blood/article-pdf/65/2/340/362003/340.pdf |
| Ending Page | 344 |
| Page Count | 5 |
| Starting Page | 340 |
| DOI | 10.1182/blood.v65.2.340.bloodjournal652340 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 65 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1985-02-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Survival Phenotype Leukemia Prognostic Lymphocytic Maturation Cll Binet Smlg Journal: Blood (Vol- 51, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
