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Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Principe, Maria Ilaria del Poeta, Giovanni D. E. L. Buccisano, Francesco Maurillo, Luca Venditti, Adriano Zucchetto, Antonella Marini, Rita Niscola, Pasquale Consalvo, Maria Antonietta Irno Mazzone, Carla Ottaviani, Licia Panetta, Paola Bruno, Antonio Bomben, Riccardo Suppo, Giovanna Degan, Massimo Gattei, Valter de Fabritiis, Paolo Cantonetti, Maria Coco, Francesco Lo Principe, Domenico Del Amadori, Sergio |
| Copyright Year | 2006 |
| Description | The clinical course of B-cell chronic lymphocytic leukemia (B-CLL) is variable, and novel biologic parameters need to be added to the clinical staging systems to predict an indolent or aggressive outcome. We investigated the 70-kDa zeta-associated protein (ZAP-70), CD38, soluble CD23 (sCD23), and cytogenetics in 289 patients with B-CLL. Both a shorter progression-free survival (PFS) and overall survival (OS) were observed in ZAP-70+ (P < .001), in CD38+ (P < .001) and in sCD23+ patients (P < .001 and P = .013, respectively). ZAP-70+CD38+ or ZAP-70+ patients with an unmutated IgVH status showed both a shorter PFS (P < .001) and OS (P < .001 and P < .001, respectively) as compared with ZAP-70–/CD38– or ZAP-70– patients with mutated IgVH genes. Discordant patients showed an intermediate outcome. Note, ZAP-70+ patients even if CD38– or mutated showed a shorter PFS, whereas ZAP-70– patients even if CD38+ or unmutated had a longer PFS. Furthermore, ZAP-70 positivity was associated with a shorter PFS both within normal karyotype (P < .001) and within the poor-risk cytogenetic subset (P = .02). The predictive value of ZAP-70 expression was confirmed in multivariate analysis. Thus, ZAP-70 protein determined by flow cytometry improves the prognostic significance of cytogenetics and appears to be a better predictor of outcomes than IgVH gene mutational status. On this line, we recommend and are also interested in conducting a prospective randomized trial of early intervention versus observation for ZAP-70+ patients. |
| Related Links | http://www.bloodjournal.org/content/108/3/853.full.pdf |
| Ending Page | 861 |
| Page Count | 9 |
| Starting Page | 853 |
| DOI | 10.1182/blood-2005-12-4986 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 108 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2006-08-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Multivariate Analysis Protein Survival Leukemia Lymphocytic Cll Scd23 Zap Shorter Journal: Blood (Vol- 71, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
