NDLI: Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation

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Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation

Content Provider	Scilit
Author	Molineux, G. Hartley, Ca McElroy, P. McCrea, C. Mcniece, Ik
Copyright Year	1996
Description	Megakaryocyte growth and development factor (MGDF) is a recently characterized ligand for the cell surface receptor mpl. We have evaluated the effects of polyethylene glycollated recombinant human MGDF (PEG-rHuMGDF) on recovery of hematopoietic cells in mice following bone marrow transplantation (BMT) to support lethal irradiation. Mice treated with PEG-rHuMGDF (50 micrograms/kg/d) had accelerated recovery of platelet numbers compared with BMT mice treated with carrier or recombinant human granulocyte colony-stimulating factor (rHuG-CSF, 72 or 200 micrograms/kg/d). In contrast, PEG-rHuMGDF had no effect on white blood cell (WBC) or red blood cell (RBC) recovery. As previously reported, animals treated with rHuG-CSF had an enhanced recovery of WBC but not platelet or RBC levels. Interestingly, BMT receipient mice treated with the combination of PEG-rHuMGDF and rHuG-CSF showed simultaneous enhanced recovery of both leukocytes and platelets. PEGylated rHuMGDF was found to be considerably more potent than non- PEGylated rHuMGDF in this setting. PEG-rHuMGDF is an effective growth factor for enhancing platelet recovery in mice following BMT either alone or in combination with rHuG-CSF. It will be of interest to evaluate in a clinical setting the ratios of PEG-rHuMGDF and rHuG-CSF for simultaneous administration of these factors and accelerated recovery of both leukocytes and platelets.
Related Links	https://ashpublications.org/blood/article-pdf/88/4/1509/621626/1509.pdf
Ending Page	1514
Page Count	6
Starting Page	1509
DOI	10.1182/blood.v88.4.1509.bloodjournal8841509
Journal	Blood
Issue Number	4
Volume Number	88
Language	English
Publisher	American Society of Hematology
Publisher Date	1996-08-15
Access Restriction	Open
Subject Keyword	Hematology Hematopoietic Bone Marrow Peg Rhumgdf Enhancing Platelet Recovery Recovery in Mice Journal: Blood (Vol- 77, Issue- 4)
Content Type	Text
Resource Type	Article

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