NDLI: Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura.

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Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura.

Content Provider	Scilit
Author	Nomura, Shosaku Dan, Kazuo Hotta, Tomomitsu Fujimura, Kingo Ikeda, Yasuo
Copyright Year	2002
Description	We conducted a phase 1-2 clinical trial to evaluate the effect of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with chronic idiopathic thrombocytopenic purpura (ITP) refractory to standard therapy who had platelet counts below 30 × $10^{9}$/L. Four patients received PEG-rHuMGDF (0.5 μg/kg of body weight per day) by daily intravenous injection for up to 7 days. Administration of PEG-rHuMGDF increased platelet counts in 3 patients. A striking thrombocytosis occurred in 2 patients, whose platelet counts were elevated to more than 700 × $10^{9}$/L a week after the last administration of PEG-rHuMGDF and returned to baseline levels within 4 to 6 weeks. Before the platelet peak, the percentage of reticulated platelets increased transiently in 3 patients tested, including one patient who had no response. Bleeding episodes decreased after the start of PEG-rHuMGDF therapy. These results suggest that PEG-rHuMGDF might have a clinical benefit in ameliorating thrombocytopenia associated with ITP.
Related Links	http://www.bloodjournal.org/content/bloodjournal/100/2/728.full.pdf
Ending Page	730
Page Count	3
Starting Page	728
DOI	10.1182/blood.v100.2.728
Journal	Blood
Issue Number	2
Volume Number	100
Language	English
Publisher	American Society of Hematology
Publisher Date	2002-06-28
Access Restriction	Open
Subject Keyword	Hematology Purpura Idiopathic Administration Recombinant Megakaryocyte Thrombocytopenic Pegylated Platelet Counts Peg Rhumgdf Journal: Blood (Vol- 59, Issue- 2)
Content Type	Text
Resource Type	Article

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