NDLI: Menin regulates the function of hematopoietic stem cells and lymphoid progenitors

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Menin regulates the function of hematopoietic stem cells and lymphoid progenitors

Content Provider	Scilit
Author	Maillard, Ivan Chen, Ya-Xiong Friedman, Ann Yang, Yuqing Tubbs, Anthony T. Shestova, Olga Pear, Warren S. Hua, Xianxin
Copyright Year	2009
Description	Men1 is a tumor suppressor gene mutated in endocrine neoplasms. Besides its endocrine role, the Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysine 4 methyltransferase. Although menin and MLL fusion proteins cooperate to activate Homeobox (Hox) gene expression during transformation, little is known about the normal hematopoietic functions of menin. Here, we studied hematopoiesis after Men1 ablation. Menin loss modestly impaired blood neutrophil, lymphocyte, and platelet counts. Without hematopoietic stress, multilineage and myelo-erythroid bone marrow progenitor numbers were preserved, while B lymphoid progenitors were decreased. In contrast, competitive transplantation revealed a marked functional defect of long-term hematopoietic stem cells (HSC) in the absence of menin, despite normal initial homing of progenitors to the bone marrow. HoxA9 gene expression was only modestly decreased in menin-deficient HSCs. These observations reveal a novel and essential role for menin in HSC homeostasis that was most apparent during situations of hematopoietic recovery, suggesting that menin regulates molecular pathways that are essential during the adaptive HSC response to stress.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647667/pdf
Ending Page	1669
Page Count	9
Starting Page	1661
DOI	10.1182/blood-2009-01-135012
Journal	Blood
Issue Number	8
Volume Number	113
Language	English
Publisher	American Society of Hematology
Publisher Date	2009-02-19
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Response To Stress Menin Bone Marrow Gene Expression Tumor Suppressor Gene Neutrophil Histone Men1 Platelet Counts Lymphoid Progenitors Journal: Blood (Vol- 105, Issue- 8)
Content Type	Text
Resource Type	Article

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