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Mll5 contributes to hematopoietic stem cell fitness and homeostasis
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Yan Wong, Jasmine Klinger, Mark Tran, Mary T. Shannon, Kevin M. Killeen, Nigel |
| Copyright Year | 2009 |
| Description | MLL5 is a novel trithorax group gene and a candidate tumor suppressor gene located within a 2.5-Mb interval of chromosome band 7q22 that frequently is deleted in human myeloid malignancy. Here we show that inactivation of the Mll5 gene in mice results in a 30% reduction in the average representation of hematopoietic stem cells and in functional impairment of long-term hematopoietic repopulation potential under competitive conditions. Bone marrow cells from Mll5-deficient mice were defective in spleen colony-forming assays, and the mutant mice showed enhanced susceptibility to 5-fluorouracil–induced myelosuppression. Heterozygous and homozygous Mll5 mutant mice did not spontaneously develop hematologic cancers, and loss of Mll5 did not alter the phenotype of a fatal myeloproliferative disorder induced by oncogenic Kras in vivo. Collectively, the data reveal an important role for Mll5 in HSC homeostasis and provide a basis for further studies to explore its role in leukemogenesis. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644073/pdf |
| Ending Page | 1463 |
| Page Count | 9 |
| Starting Page | 1455 |
| DOI | 10.1182/blood-2008-05-159905 |
| Journal | Blood |
| Issue Number | 7 |
| Volume Number | 113 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2009-02-12 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Gene and A Candidate Mll5 Mice Tumor Suppressor Gene Trithorax Bone Marrow Cells Stem Cell Hematopoietic Journal: Blood (Vol- 100, Issue- 7) |
| Content Type | Text |
| Resource Type | Article |
