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Mutations in the Wilms' tumor gene WT1 in leukemias
| Content Provider | Scilit |
|---|---|
| Author | King-Underwood, L. Renshaw, J. Pritchard-Jones, Kathryn |
| Copyright Year | 1996 |
| Description | The tissue-specific Wilms' tumor gene WT1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the WT1 gene in 4 of 36 acute leukemias. WT1 mutations are found in 15% of cases of acute myeloid leukemia, in which they are associated with a poor response to chemotherapy. The mutations comprise small insertions in exons 1 and 7 and a nonsense mutation in exon 9. All are predicted to produce a truncated WT1 protein with absence or disruption of the zinc finger region. These are the first mutations in the WT1 gene to be described in sporadic leukemia. |
| Related Links | https://ashpublications.org/blood/article-pdf/87/6/2171/620886/2171.pdf |
| Ending Page | 2179 |
| Page Count | 9 |
| Starting Page | 2171 |
| DOI | 10.1182/blood.v87.6.2171.bloodjournal8762171 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 87 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1996-03-15 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Protein Hematopoietic Leukemias Tissue Conformational Wilms Exons Wt1 Gene Comprise Journal: Blood (Vol- 89, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |
