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Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
| Content Provider | Scilit |
|---|---|
| Author | Becker, Heiko Marcucci, Guido Maharry, Kati Radmacher, Michael D. Mrózek, Krzysztof Margeson, Dean Whitman, Susan P. Paschka, Peter Holland, Kelsi B. Schwind, Sebastian Wu, Yue-Zhong Powell, Bayard L. Carter, Thomas H. Kolitz, Jonathan E. Wetzler, Meir Carroll, Andrew J. Baer, Maria R. Moore, Joseph O. Caligiuri, Michael A. Larson, Richard A. Bloomfield, Clara D. |
| Copyright Year | 2010 |
| Description | We previously reported the adverse prognostic impact of Wilms tumor 1 gene (WT1) mutations in younger adult cytogenetically normal acute myeloid leukemia (CN-AML). Here, we investigated 243 older (≥ 60 years) primary CN-AML patients. WT1 mutated (WT1mut) patients (7%) had FLT3-ITD more frequently (P < .001), lower hemoglobin (P = .01), higher white blood cell count (P = .03) and percentage blood blasts (P = .03), and a shorter overall survival (P = .08) than WT1 wild-type (WT1wt) patients. Comparing older and younger WT1mut patients, they had similar pretreatment characteristics and outcome. By contrast, among WT1wt CN-AML, younger patients had a significantly better outcome. A WT1 mutation-associated gene-expression signature, reported here for the first time, included CD96, a leukemia stem cell-specific marker, and genes involved in gene regulation (eg, MLL, PML, and SNRPN) and in proliferative and metabolic processes (eg, INSR, IRS2, and PRKAA1), supporting the role of mutated WT1 in deregulating multiple homeostatic processes. Our results indicate that WT1mut CN-AML represents a distinct entity with poor treatment response across age groups. This study has been registered at www.clinicaltrials.gov as #NCT00900224. |
| Related Links | http://www.bloodjournal.org/content/116/5/788.full.pdf |
| Ending Page | 792 |
| Page Count | 5 |
| Starting Page | 788 |
| DOI | 10.1182/blood-2010-01-262543 |
| Journal | Blood |
| Issue Number | 5 |
| Volume Number | 116 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2010-08-05 |
| Access Restriction | Open |
| Subject Keyword | Hematology Research and Experimental Medicine Acute Myeloid Leukemia Aml Wt1 Age Groups Cytogenetically White Blood Cell Mutated Wilms Tumor Normal Acute Journal: Blood (Vol- 84, Issue- 5) |
| Content Type | Text |
| Resource Type | Article |
