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Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK
| Content Provider | Scilit |
|---|---|
| Author | Kim, Ekaterina Hurtz, Christian Koehrer, Stefan Wang, Zhiqiang Balasubramanian, Sriram Chang, Betty Y. Müschen, Markus Davis, R. Eric Burger, Jan A. |
| Copyright Year | 2017 |
| Description | Key Points In B-ALL, cells that express a functional pre-BCR ibrutinib abrogate leukemia cell growth in vitro and in vivo. Effects of ibrutinib in B-ALL not only are mediated through inhibition of BTK but also involve BLK inhibition. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374732/pdf |
| Ending Page | 1165 |
| Page Count | 11 |
| Starting Page | 1155 |
| DOI | 10.1182/blood-2016-06-722900 |
| Journal | Blood |
| Issue Number | 9 |
| Volume Number | 129 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2017-03-02 |
| Access Restriction | Open |
| Subject Keyword | Hematology Ibrutinib Pre Bcr Btk Functional Lymphoblastic Abrogate Leukemia Blk Journal: Blood (Vol- 110, Issue- 9) |
| Content Type | Text |
| Resource Type | Article |