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Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice
| Content Provider | Scilit |
|---|---|
| Author | Kon, Ayana Yamazaki, Satoshi Nannya, Yasuhito Kataoka, Keisuke Ota, Yasunori Nakagawa, Masahiro Marshall Yoshida, Kenichi Shiozawa, Yusuke Morita, Maiko Yoshizato, Tetsuichi Sanada, Masashi Nakayama, Manabu Koseki, Haruhiko Nakauchi, Hiromitsu Ogawa, Seishi |
| Copyright Year | 2018 |
| Description | Key Points Blood-specific expression of the Srsf2 P95H mutant results in decreased stem/progenitor cell numbers and a reduced repopulation capacity. Srsf2 P95H mutation by itself is not sufficient to develop MDS but contributes to the MDS phenotype in transplantation settings. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888285/pdf |
| Ending Page | 635 |
| Page Count | 15 |
| Starting Page | 621 |
| DOI | 10.1182/blood-2017-01-762393 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 131 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-02-08 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Hematopoietic Stem Functions Rna Splicing Expressed Genes Mutated Hspcs Mutant Srsf2 Journal: Blood (Vol- 91, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |