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Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl
| Content Provider | Scilit |
|---|---|
| Author | Xiao, Nan Laha, Suparna Das, Shankar P. Morlock, Kayla Jesneck, Jonathan L. Raffel, Glen D. |
| Copyright Year | 2015 |
| Description | Key Points Ott1 regulates the alternative splicing of Mpl-TR, a truncated isoform of c-Mpl, which modulates Thpo-mediated signaling. Mpl-TR expression impairs HSC engraftment. |
| Related Links | https://ashpublications.org/blood/article-pdf/125/6/941/1387586/941.pdf |
| Ending Page | 948 |
| Page Count | 8 |
| Starting Page | 941 |
| DOI | 10.1182/blood-2014-08-593392 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 125 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2015-02-05 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Epigenetic Alternative Splicing Histone Ott1 Acetylation Thrombopoietin Thpo Mpl Chromatin Journal: Blood (Vol- 91, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |