Loading...
Please wait, while we are loading the content...
Similar Documents
161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS
| Content Provider | Scilit |
|---|---|
| Author | Sarhan, Dhifaf Brandt, Ludwig Felices, Martin Guldevall, Karolin Lenvik, Todd Hinderlie, Peter Curtsinger, Julie Warlick, Erica Spellman, Stephen R. Blazar, Bruce R. Weisdorf, Daniel J. Cooley, Sarah Vallera, Daniel A. Önfelt, Björn Miller, Jeffrey S. |
| Copyright Year | 2018 |
| Description | Key Points 161533 TriKE–treated MDS NK cells proliferate and become activated to overcome tumor-induced NK cell dysfunction. IL-15 induces the inhibitory checkpoint TIGIT on NK cells, but not when IL-15 is presented in the context of 161533 TriKE. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020813/pdf |
| Ending Page | 1469 |
| Page Count | 11 |
| Starting Page | 1459 |
| DOI | 10.1182/bloodadvances.2017012369 |
| Journal | Blood advances |
| Issue Number | 12 |
| Volume Number | 2 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2018-06-26 |
| Access Restriction | Open |
| Subject Keyword | Immunology Checkpoint Nk Cells Dysfunction Mds Suppressor Trike Overcome Stimulates Journal: Blood advances (Vol- 118, Issue- 12) |
| Content Type | Text |
| Resource Type | Article |