NDLI: How I treat disseminated intravascular coagulation

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How I treat disseminated intravascular coagulation

Content Provider	Scilit
Author	Levi, Marcel Scully, Marie
Copyright Year	2018
Description	Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation proteins results in thrombocytopenia and low concentrations of clotting factors, which may cause profuse hemorrhagic complications. DIC is always secondary to an underlying condition, such as severe infections, solid or hematologic malignancies, trauma, or obstetric calamities. A reliable diagnosis of DIC can be made through simple scoring algorithms based on readily available routine hemostatic parameters. The cornerstone of supportive treatment of this coagulopathy is management of the underlying condition. Additionally, administration of heparin may be useful, and restoration of physiological anticoagulants has been suggested, but has not been proven successful in improving clinically relevant outcomes so far. In patients with major bleeding or at risk for hemorrhagic complications, administration of platelet concentrates, plasma, or coagulation factor concentrates should be considered.
Related Links	http://www.bloodjournal.org/content/131/8/845.full.pdf
Ending Page	854
Page Count	10
Starting Page	845
DOI	10.1182/blood-2017-10-804096
Journal	Blood
Issue Number	8
Volume Number	131
Language	English
Publisher	American Society of Hematology
Publisher Date	2018-02-22
Access Restriction	Open
Subject Keyword	Anesthesiology Treatment Proteins Platelet Complications Dic Disseminated Intravascular Coagulation Administration Hemorrhagic Journal: Blood (Vol- 106, Issue- 8)
Content Type	Text
Resource Type	Article

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