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The differentiation program of embryonic definitive hematopoietic stem cells is largely α4 integrin independent
| Content Provider | Scilit |
|---|---|
| Author | Gribi, Ruby Hook, Lilian Ure, Janice Medvinsky, Alexander |
| Copyright Year | 2006 |
| Description | Previous analyses of the roles of α4 integrins in hematopoiesis by other groups have led to conflicting evidence. α4 integrin mutant cells developing in [α4 integrin–/–: wt] chimeric mice are not capable of completing lymphomyeloid differentiation, whereas conditional inactivation of α4 integrin in adult mice has only subtle effects. We show here that circumventing the fetal stage of hematopoietic stem cell (HSC) development by transplantation of embryonic α4 integrin–/– cells into the adult microenvironment results in robust and stable long-term generation of α4 integrin–/– lymphoid and myeloid cells, although colonization of Peyer patches and the peritoneal cavity is significantly impaired. We argue here that collectively, our data and the data from other groups suggest a specific requirement for α4 integrin during the fetal/neonatal stages of HSC development that is essential for normal execution of the lymphomyeloid differentiation program. |
| Related Links | http://bloodjournal.hematologylibrary.org/content/108/2/501.full.pdf |
| Ending Page | 509 |
| Page Count | 9 |
| Starting Page | 501 |
| DOI | 10.1182/blood-2005-10-4209 |
| Journal | Blood |
| Issue Number | 2 |
| Volume Number | 108 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2006-07-15 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Differentiation Program Robust and Stable Hematopoietic Stem Stem Cell Integrin Mice Lymphomyeloid Differentiation Journal: Blood (Vol- 59, Issue- 2) |
| Content Type | Text |
| Resource Type | Article |
