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The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients [see comments]
| Content Provider | Scilit |
|---|---|
| Author | Mills, Ki Kenzie, Ed Mac Birnie, Gd |
| Copyright Year | 1988 |
| Description | The Philadelphia (Ph1) chromosome, characteristic of chronic myelogenous leukemia (CML), arises from a reciprocal translocation between chromosomes 9 and 22. The site of the breakpoint on chromosome 22 is within a small region called the breakpoint cluster region (bcr). We have mapped the breakpoint within the bcr in peripheral blood leukocyte DNA from 22 Ph1-positive CML patients. No correlation between the site of the breakpoint and the clinical phase of the disease was found. However, a striking correlation between the site of the breakpoint and the length of time between presentation and onset of acute phase was observed: on average, patients with a 5′ break-point had a fourfold longer chronic phase (median, 203 weeks) than those with a 3′ breakpoint (median, 52 weeks). |
| Related Links | https://ashpublications.org/blood/article-pdf/72/4/1237/216248/1237.pdf |
| Ending Page | 1241 |
| Page Count | 5 |
| Starting Page | 1237 |
| DOI | 10.1182/blood.v72.4.1237.bloodjournal7241237 |
| Journal | Blood |
| Issue Number | 4 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1988-10-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Chromosome Bcr Cml Philadelphia See Myelogenous Site of the Breakpoint Journal: Blood (Vol- 76, Issue- 4) |
| Content Type | Text |
| Resource Type | Article |
