NDLI: CML-T1: a cell line derived from T-lymphocyte acute phase of chronic myelogenous leukemia

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CML-T1: a cell line derived from T-lymphocyte acute phase of chronic myelogenous leukemia

Content Provider	Scilit
Author	Kuriyama, K. Gale, Rp Tomonaga, M. Ikeda, S. Yao, E. Klisak, I. Whelan, K. Yakir, H. Ichimaru, M. Sparkes, Rs
Copyright Year	1989
Description	Most data suggest that malignant transformation in chronic myelogenous leukemia (CML) occurs in hematopoietic stem cell that is the progenitor of myelopoiesis and of B but not T lymphopoiesis. We established a T- lymphoid cell line (CML-T1) from a person with Ph-chromosome-negative CML in acute phase. Evidence of its T-lymphocyte origin includes the pattern cytochemical reactivity, reactivity with anti-T-cell monoclonal antibodies (MoAbs), and rearrangement of the beta-T-cell receptor (TCRB) gene. CML-T1 cells have features of type IV thymocytes. Cytogenetic analyses indicate a 47,XX, del(11), t(6;7)(q23;q24), +mar karyotype. CML-T1 cells exhibit molecular changes typical of CML, including translocation of the ABL protooncogene from chromosome 9 to 22, rearrangement of the BCR gene, and transcription of a chimeric BCR- ABL messenger RNA (mRNA). The ABL insertion on chromosome 22 appears interstitial, similar to other cases of Ph-chromosome-negative CML. These data clearly indicate that T cells can be involved in acute-phase CML. CML-T1 should be useful in studying this process as well as that underlying Ph-chromosome-negative CML.
Related Links	https://ashpublications.org/blood/article-pdf/74/4/1381/216379/1381.pdf
Ending Page	1387
Page Count	7
Starting Page	1381
DOI	10.1182/blood.v74.4.1381.bloodjournal7441381
Journal	Blood
Issue Number	4
Volume Number	74
Language	English
Publisher	American Society of Hematology
Publisher Date	1989-09-01
Access Restriction	Open
Subject Keyword	Hematology Hematopoietic Antibodies Leukemia Chromosome Bcr Mar Myelogenous Cml T1 Journal: Blood (Vol- 76, Issue- 4)
Content Type	Text
Resource Type	Article

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