NDLI: Memory Phenotype of CD8+ T Cells in MHC Class Ia-Deficient Mice

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Memory Phenotype of CD8+ T Cells in MHC Class Ia-Deficient Mice

Content Provider	Scilit
Author	Kurepa, Zoran Su, Jie Forman, James
Copyright Year	2003
Description	$B6.K^{b−}D^{b−}$ mice are devoid of class Ia but express normal levels of class Ib molecules. They have low levels of CD8 T cells in both the thymus as well as peripheral T cell compartments. Although the percentage of splenic CD8αα T cells is increased in these animals, ∼90% of CD8 T cells are CD8αβ. In contrast to B6 animals, most of the CD8 T cells from these mice have a memory phenotype $(CD44^{high}CD122^{high}$ $CD62L^{low}$) including both CD8αβ and CD8αα subsets. In the thymus of $B6.K^{b−}D^{b−}$ animals, there is a decrease in the percentage of SP CD8 T cells, although most are $CD44^{low}$, similar to that seen in B6 mice. The spleens from day 1-old B6 and $B6.K^{b−}D^{b−}$ mice have a relatively high proportion of $CD44^{high}CD62L^{low}$ CD8 T cells. However, by day 28 most CD8 T cells in B6 mice have a naive phenotype while in $B6.K^{b−}D^{b−}$ mice the memory phenotype remains. Unlike $CD44^{high}$ cells that are found in B6 animals, most $CD44^{high}$ cells from $B6.K^{b−}D^{b−}$ mice do not secrete IFN-γ rapidly upon activation. The paucity of CD8 T cells in $B6.K^{b−}D^{b−}$ mice might be due in part to their inability to undergo homeostatic expansion. Consistent with this, we found that CD8 T cells from these animals expand poorly in X-irradiated syngeneic hosts compared with B6 CD8 T cells that respond to class Ia Ags. We examined homeostatic expansion of B6 CD8 T cells in single as well as double class Ia knockout mice and were able to estimate the fraction of cells reactive against class Ia vs class Ib molecules.
Ending Page	5420
Page Count	7
Starting Page	5414
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.170.11.5414
Alternate Webpage(s)	http://www.jimmunol.org/content/170/11/5414.full.pdf
Journal	The Journal of Immunology
Issue Number	11
Volume Number	170
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2003-06-01
Access Restriction	Open
Subject Keyword	B6.k Cd8 T Cells Class Ia
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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