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TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling
| Content Provider | Scilit |
|---|---|
| Author | Xie, Ping Kraus, Zachary J. Stunz, Laura L. Liu, Yan Bishop, Gail A. |
| Copyright Year | 2011 |
| Description | We recently reported that TNFR-associated factor (TRAF)3, a ubiquitously expressed adaptor protein, promotes mature B cell apoptosis. However, the specific function of TRAF3 in T cells has remained unclear. In this article, we report the generation and characterization of T cell-specific $TRAF3^{−/−}$ mice, in which the traf3 gene was deleted from thymocytes and T cells. Ablation of TRAF3 in the T cell lineage did not affect CD4 or CD8 T cell populations in secondary lymphoid organs or the numbers or proportions of $CD4^{+},CD8^{+}$ or double-positive or double-negative thymocytes, except that the T cell-specific $TRAF3^{−/−}$ mice had a 2-fold increase in $FoxP3^{+}$ T cells. In striking contrast to mice lacking TRAF3 in B cells, the T cell TRAF3-deficient mice exhibited defective IgG1 responses to a T-dependent Ag, as well as impaired T cell-mediated immunity to infection with Listeria monocytogenes. Surprisingly, we found that TRAF3 was recruited to the TCR/CD28 signaling complex upon costimulation and that TCR/CD28-mediated proximal and distal signaling events were compromised by TRAF3 deficiency. These findings provide insights into the roles played by TRAF3 in T cell activation and T cell-mediated immunity. |
| Ending Page | 155 |
| Page Count | 13 |
| Starting Page | 143 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1000290 |
| Journal | The Journal of Immunology |
| Issue Number | 1 |
| Volume Number | 186 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Subject Keyword | Tcr/cd28 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
