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Regulators of G Protein Signaling Exhibit Distinct Patterns of Gene Expression and Target G Protein Specificity in Human Lymphocytes
| Content Provider | Scilit |
|---|---|
| Author | Beadling, Carol Druey, Kirk M. Richter, Gunther Kehrl, John H. Smith, Kendall A. |
| Copyright Year | 1999 |
| Description | The newly recognized regulators of G protein signaling (RGS) attenuate heterotrimeric G protein signaling pathways. We have cloned an IL-2-induced gene from human T cells, cytokine-responsive gene 1, which encodes a member of the RGS family, RGS16. The RGS16 protein binds $G_{iα}$ and $G_{qα}$ proteins present in T cells, and inhibits $G_{i}$- and $G_{q}$-mediated signaling pathways. By comparison, the mitogen-induced RGS2 inhibits $G_{q}$ but not $G_{i}$ signaling. Moreover, the two RGS genes exhibit marked differences in expression patterns. The IL-2-induced expression of the RGS16 gene in T cells is suppressed by elevated cAMP, whereas the RGS2 gene shows a reciprocal pattern of regulation by these stimuli. Because the mitogen and cytokine receptors that trigger expression of RGS2 and RGS16 in T cells do not activate heterotrimeric G proteins, these RGS proteins and the G proteins that they regulate may play a heretofore unrecognized role in T cell functional responses to Ag and cytokine activation. |
| Ending Page | 2682 |
| Page Count | 6 |
| Starting Page | 2677 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.162.5.2677 |
| Journal | The Journal of Immunology |
| Issue Number | 5 |
| Volume Number | 162 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 1999-03-01 |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Protein Signaling Heterotrimeric G Proteins |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
