NDLI: Rapid Production of TNF-α following TCR Engagement of Naive CD8 T Cells

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Rapid Production of TNF-α following TCR Engagement of Naive CD8 T Cells

Content Provider	Scilit
Author	Brehm, Michael A. Daniels, Keith A. Welsh, Raymond M.
Copyright Year	2005
Description	The acquisition of effector functions by naive CD8 T cells following TCR engagement is thought to occur sequentially with full functionality being gained only after the initiation of division. We show that naive CD8 T cells are capable of immediate effector function following TCR engagement, which stimulates the rapid production of TNF-α. Stimulation of splenocytes from naive mice of differing genetic backgrounds with anti-CD3ε mAb resulted in significant production of TNF-α by naive CD8 T cells within 5 h. Moreover, naive lymphocytic choriomeningitis virus-specific TCR-transgenic CD8 T cells stimulated with either their cognate peptide ligand or virus-infected cells produced TNF-α as early as 2 h poststimulation, with production peaking by 4 h. Naive CD8 T cells produced both membrane-bound and soluble TNF-α. Interfering with TNF-α activity during the initial encounter between naive CD8 T cells and Ag loaded dendritic cells altered the maturation profile of the APC and diminished the overall viability of the APC population. These findings suggest that production of TNF-α by naive CD8 T cells immediately after TCR engagement may have an unappreciated impact within the local environment where Ag presentation is occurring and potentially influence the development of immune responses.
Ending Page	5049
Page Count	7
Starting Page	5043
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.175.8.5043
Journal	The Journal of Immunology
Issue Number	8
Volume Number	175
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2005-10-15
Access Restriction	Open
Subject Keyword	Naive Cd8 Tnf Α Cd8 T Cells
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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