Loading...
Please wait, while we are loading the content...
Similar Documents
Cutting Edge: IFN-γ Enables APC to Promote Memory Th17 and Abate Th1 Cell Development
| Content Provider | Scilit |
|---|---|
| Author | Kryczek, Ilona Wei, Shuang Gong, Wenrong Shu, Xiaogong Szeliga, Wojciech Vatan, Linhua Chen, Lieping Wang, Guobin Zou, Weiping |
| Copyright Year | 2008 |
| Description | Th1-derived IFN-γ targets naive T cells and inhibits Th17 development. However, Th1, Th17, and memory but not naive T cells are colocalized in an inflammatory environment. To demonstrate the kinetic relationship between these T cell subsets, we investigated the role of IFN-γ in regulating the development and balance between Th17 and Th1 in humans. We show that IFN-γ stimulates B7-H1 expression on APC subsets and abates their Th1 polarization capacity in a B7-H1-dependent manner. Interestingly, IFN-γ triggers APCs to produce IL-1 and IL-23 and enables them to induce memory Th17 expansion via IL-1 and IL-23 in a B7-H1-independent manner. We propose a novel dynamic between Th1 and Th17 in the course of inflammation as follows: Th1-mediated inflammation is attenuated by IFN-γ-induced B7-H1 on APCs and is evolved toward Th17-mediated chronic inflammation by IFN-γ-induced, APC-derived IL-1 and IL-23. Our study challenges the dogma that IFN-γ suppresses Th17 and enhances Th1 development. |
| Ending Page | 5846 |
| Page Count | 5 |
| Starting Page | 5842 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.181.9.5842 |
| Journal | The Journal of Immunology |
| Issue Number | 9 |
| Volume Number | 181 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2008-11-01 |
| Access Restriction | Open |
| Subject Keyword | Ifn Γ |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
