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Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation
| Content Provider | Scilit |
|---|---|
| Author | Fields, Patrick E. Kim, Sean T. Flavell, Richard A. |
| Copyright Year | 2002 |
| Description | Peripheral T cell differentiation is accompanied by chromatin changes at the signature cytokine loci. Using chromatin immunoprecipitation we demonstrate that profound increases in histone acetylation occur at the IFN-γ and IL-4 loci during Th1/Th2 differentiation. These changes in histone acetylation status are locus and lineage specific, and are maintained by the transcription factors Tbet and GATA3 in a STAT-dependent manner. Our results suggest a model of cytokine locus activation in which TCR signals initiate chromatin remodeling and locus opening in a cytokine-independent fashion. Subsequently, cytokine signaling reinforces polarization by expanding and maintaining the accessible state at the relevant cytokine locus (IL-4 or IFN-γ). In this model, GATA3 and Tbet serve as transcriptional maintenance factors, which keep the locus accessible to the transcriptional machinery. |
| Ending Page | 650 |
| Page Count | 4 |
| Starting Page | 647 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.169.2.647 |
| Journal | The Journal of Immunology |
| Issue Number | 2 |
| Volume Number | 169 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2002-07-15 |
| Access Restriction | Open |
| Subject Keyword | Transcription Factors Histone Acetylation Th1/th2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
