NDLI: Functional Characterization of MHC Class II-Restricted CD8+CD4− and CD8−CD4− T Cell Responses to Infection in CD4−/− Mice

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Functional Characterization of MHC Class II-Restricted CD8+CD4− and CD8−CD4− T Cell Responses to Infection in CD4−/− Mice

Content Provider	Scilit
Author	Pearce, Erika L. Shedlock, Devon J. Shen, Hao
Copyright Year	2004
Description	Classical $CD4^{+}$ and $CD8^{+}$ T cells recognize Ag presented by MHC class II (MHCII) and MHC class I (MHCI), respectively. However, our results show that $CD4^{−/−}$ mice mount a strong, readily detectable $CD8^{+}$ T cell response to MHCII-restricted epitopes after a primary bacterial or viral infection. These MHCII-restricted $CD8^{+}CD4^{−}$ T cells are more similar to classical $CD8^{+}$ T cells than to $CD4^{+}$ T cells in their expression of effector functions during a primary infection, yet they also differ from MHCI-restricted $CD8^{+}$ T cells by their inability to produce high levels of the cytolytic molecule granzyme B. After resolution of a primary infection, epitope-specific MHCII-restricted T cells in $CD4^{−/−}$ mice persist for a long period of time as memory T cells. Surprisingly, upon reinfection the secondary MHCII-restricted response in $CD4^{−/−}$ mice consists mainly of $CD8^{−}CD4^{−}$ T cells. In contrast to $CD8^{+}$ T cells, MHCII-restricted $CD8^{−}CD4^{−}$ T cells are capable of producing IL-2 in addition to IFN-γ and thus appear to have attributes characteristic of $CD4^{+}$ T cells rather than $CD8^{+}$ T cells. Therefore, MHCII-restricted T cells in $CD4^{−/−}$ mice do not share all phenotypic and functional characteristics with MHCI-restricted $CD8^{+}$ T cells or with MHCII-restricted $CD4^{+}$ T cells, but, rather, adopt attributes from each of these subsets. These results have implications for understanding thymic T cell selection and for elucidating the mechanisms regulating the peripheral immune response and memory differentiation.
Ending Page	2499
Page Count	6
Starting Page	2494
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.173.4.2494
Alternate Webpage(s)	https://www.jimmunol.org/content/jimmunol/173/4/2494.full.pdf
Journal	The Journal of Immunology
Issue Number	4
Volume Number	173
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2004-08-15
Access Restriction	Open
Subject Keyword	Mhcii Restricted Mhci Restricted Restricted T Cells
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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