NDLI: Severe Perturbations of the Blood T Cell Repertoire in Polymyositis, But Not Dermatomyositis Patients

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Severe Perturbations of the Blood T Cell Repertoire in Polymyositis, But Not Dermatomyositis Patients

Content Provider	Scilit
Author	Benveniste, Olivier Chérin, Patrick Maisonobe, Thierry Merat, Rastine Chosidow, Olivier Mouthon, Luc Guillevin, Loïc Flahault, Antoine Burland, Marie-Christine Klatzmann, David Herson, Serge Boyer, Olivier
Copyright Year	2001
Description	Polymyositis and dermatomyositis are diseases characterized by muscle weakness and muscle inflammatory infiltrates. Their pathogenesis remains unclear. A central role for endomysial autoaggressive $CD8^{+}$ T cells is suspected in polymyositis and for perivascular B cells in dermatomyositis. We compared the T cell repertoire of 10 polymyositis and 10 dermatomyositis patients by immunoscope, a method providing a global assessment of the T cell repertoire and a sensitive detection of clonal T cell expansions. Samples were analyzed qualitatively and quantitatively in the blood (unsorted cells and $CD4^{+}$ and $CD8^{+}$ cells) and in muscle infiltrates. Dramatic perturbations of the T cell repertoire were observed in the blood of polymyositis but not dermatomyositis patients (p < 0.0005), the latter being undistinguishable from controls. These perturbations were due to oligoclonal expansions of $CD8^{+}$ T cells and most blood clonal expansions were also found in muscle. These results indicate that the pathogenesis of polymyositis and dermatomyositis is different and reinforce the view that polymyositis but not dermatomyositis is an autoimmune $CD8^{+}$ T cell-mediated disease. Moreover, this method may be helpful for the differential diagnosis of polymyositis and dermatomyositis and for noninvasive follow-up of polymyositis patients.
Ending Page	3529
Page Count	9
Starting Page	3521
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.167.6.3521
Journal	The Journal of Immunology
Issue Number	6
Volume Number	167
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2001-09-15
Access Restriction	Open
Subject Keyword	Cell Repertoire Dermatomyositis Patients Cells and Most Blood
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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