NDLI: MHC Drives TCR Repertoire Shaping, but not Maturation, in Recent Thymic Emigrants

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MHC Drives TCR Repertoire Shaping, but not Maturation, in Recent Thymic Emigrants

Content Provider	Scilit
Author	Houston, Evan G. Fink, Pamela J.
Copyright Year	2009
Description	After developing in the thymus, recent thymic emigrants (RTEs) enter the lymphoid periphery and undergo a maturation process as they transition into the mature naive (MN) T cell compartment. This maturation presumably shapes RTEs into a pool of T cells best fit to function robustly in the periphery without causing autoimmunity; however, the mechanism and consequences of this maturation process remain unknown. Using a transgenic mouse system that specifically labels RTEs, we tested the influence of MHC molecules, key drivers of intrathymic T cell selection and naive peripheral T cell homeostasis, in shaping the RTE pool in the lymphoid periphery. We found that the TCRs expressed by RTEs are skewed to longer CDR3 regions compared with those of MN T cells, suggesting that MHC does streamline the TCR repertoire of T cells as they transition from the RTE to the MN T cell stage. This conclusion is borne out in studies in which the representation of individual TCRs was followed as a function of time since thymic egress. Surprisingly, we found that MHC is dispensable for the phenotypic and functional maturation of RTEs.
Ending Page	7249
Page Count	6
Starting Page	7244
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.0902313
Alternate Webpage(s)	http://www.jimmunol.org/content/183/11/7244.full.pdf
Journal	The Journal of Immunology
Issue Number	11
Volume Number	183
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-12-01
Access Restriction	Open
Subject Keyword	T Cells Cell Differentiation Repertoire Development Recent Thymic Emigrants
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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