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IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
| Content Provider | Scilit |
|---|---|
| Author | O’Neill, Emma J. O’Garra, Anne Vieira, Pedro L. Christensen, Jillian R. Minaee, Sophie Barrat, Franck J. Boonstra, André Barthlott, Thomas Stockinger, Brigitta Wraith, David C. |
| Copyright Year | 2004 |
| Description | Regulatory T cells $(T_{Reg}$) control immune responses to self and nonself Ags. The relationship between Ag-driven IL-10-secreting $T_{Reg}$ $(IL-10-T_{Reg}$) and naturally occurring $CD4^{+}CD25^{+}$ $T_{Reg}$ is as yet unclear. We show that mouse $IL-10-T_{Reg}$ obtained using either in vitro or in vivo regimens of antigenic stimulation did not express the $CD4^{+}CD25^{+}$ $T_{Reg}$-associated transcription factor Foxp3. However, despite the absence of Foxp3 expression, homogeneous populations of $IL-10-T_{Reg}$ inhibited the in vitro proliferation of $CD4^{+}CD25^{−}$ T cells with a similar efficiency to that of $CD4^{+}CD25^{+}$ $T_{Reg}$. This inhibition of T cell proliferation by $IL-10-T_{Reg}$ was achieved through an IL-10-independent mechanism as seen for $CD4^{+}CD25^{+}$ $T_{Reg}$ and was overcome by exogenous IL-2. Both $IL-10-T_{Reg}$ and $CD4^{+}CD25^{+}$ $T_{Reg}$ were similar in that they produced little to no IL-2. These data show that Foxp3 expression is not a prerequisite for $IL-10-T_{Reg}$ activity in vitro or in vivo, and suggest that $IL-10-T_{Reg}$ and naturally occurring $CD4^{+}CD25^{+}$ $T_{Reg}$ may have distinct origins. |
| Ending Page | 5993 |
| Page Count | 8 |
| Starting Page | 5986 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.172.10.5986 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/172/10/5986.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 10 |
| Volume Number | 172 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2004-05-15 |
| Access Restriction | Open |
| Subject Keyword | Transcription Factor Regulatory T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
