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Response thresholds in bacterial chemotaxis
| Content Provider | Scilit |
|---|---|
| Author | Lele, Pushkar P. Shrivastava, Abhishek Roland, Thibault Berg, Howard C. |
| Copyright Year | 2015 |
| Description | Stimulation of Escherichia coli by exponential ramps of chemoattractants generates step changes in the concentration of the response regulator, CheY-P. Because flagellar motors are ultrasensitive, this should change the fraction of time that motors spin clockwise, the $CW_{bias}$. However, early work failed to show changes in $CW_{bias}$ when ramps were shallow. This was explained by a model for motor remodeling that predicted plateaus in plots of $CW_{bias}$ versus [CheY-P]. We looked for these plateaus by examining distributions of $CW_{bias}$ in populations of cells with different mean [CheY-P]. We did not find such plateaus. Hence, we repeated the work on shallow ramps and found that motors did indeed respond. These responses were quantitatively described by combining motor remodeling with ultrasensitivity in a model that exhibited high sensitivities over a wide dynamic range. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646794/pdf https://advances.sciencemag.org/content/advances/1/9/e1500299.full.pdf |
| Ending Page | e1500299 |
| Page Count | 1 |
| Starting Page | e1500299 |
| e-ISSN | 23752548 |
| DOI | 10.1126/sciadv.1500299 |
| Journal | Science Advances |
| Issue Number | 9 |
| Volume Number | 1 |
| Language | English |
| Publisher | American Association for the Advancement of Science (AAAS) |
| Publisher Date | 2015-10-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Science Advances Flagellar Motor |
| Content Type | Text |
| Resource Type | Article |
