NDLI: Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations

Please wait, while we are loading the content...

Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations

Content Provider	Scilit
Author	Ma, Qi Sowa, Yoshiyuki Baker, Matthew A. B. Bai, Fan
Copyright Year	2016
Description	Journal: Biophysical Journal The bacterial flagellar motor (BFM) is a molecular machine that rotates the helical filaments and propels the bacteria swimming toward favorable conditions. In our previous works, we built a stochastic conformational spread model to explain the dynamic and cooperative behavior of BFM switching. Here, we extended this model to test whether it can explain the latest experimental observations regarding CheY-P regulation and motor structural adaptivity. We show that our model predicts a strong correlation between rotational direction and the number of CheY-Ps bound to the switch complex, in agreement with the latest finding from Fukuoka et al. It also predicts that the switching sensitivity of the BFM can be fine-tuned by incorporating additional units into the switch complex, as recently demonstrated by Yuan et al., who showed that stoichiometry of FliM undergoes dynamic change to maintain ultrasensitivity in the motor switching response. In addition, by locking some rotor switching units on the switch complex into the stable clockwise-only conformation, our model has accurately simulated recent experiments expressing clockwise-locked FliG(ΔPAA) into the switch complex and reproduced the increased switching rate of the motor.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816765/pdf http://www.cell.com/article/S0006349516002113/pdf
Ending Page	1420
Page Count	10
Starting Page	1411
ISSN	00063495
e-ISSN	15420086
DOI	10.1016/j.bpj.2016.02.023
Journal	Biophysical Journal
Issue Number	6
Volume Number	110
Language	English
Publisher	Elsevier BV
Publisher Date	2016-03-01
Access Restriction	Open
Subject Keyword	Journal: Biophysical Journal Switch in Response Motor Switching Response
Content Type	Text
Resource Type	Article
Subject	Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The switching mechanism of the bacterial rotary motor combines tight regulation with inherent flexibility.

Temperature dependence of switching of the bacterial flagellar motor by the protein CheY(13DK106YW).

Fluctuations in Intracellular CheY-P Concentration Coordinate Reversals of Flagellar Motors in E. coli

The Bacterial Flagellar Motor Continues to Amaze

Regulation of Switching Frequency and Bias of the Bacterial Flagellar Motor by CheY and Fumarate

Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch (2003)

Conformational spread in the bacterial flagellar switch (2010)

Switching of the bacterial flagellar motor near zero load (2009)

Only one of the five chey homologs in vibrio cholerae directly switches flagellar rotation (2004).

Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations

Similar Documents

The switching mechanism of the bacterial rotary motor combines tight regulation with inherent flexibility.

Temperature dependence of switching of the bacterial flagellar motor by the protein CheY(13DK106YW).

Fluctuations in Intracellular CheY-P Concentration Coordinate Reversals of Flagellar Motors in E. coli

The Bacterial Flagellar Motor Continues to Amaze

Regulation of Switching Frequency and Bias of the Bacterial Flagellar Motor by CheY and Fumarate

Bacillus subtilis hydrolyzes CheY-P at the location of its action, the flagellar switch (2003)

Conformational spread in the bacterial flagellar switch (2010)

Switching of the bacterial flagellar motor near zero load (2009)

Only one of the five chey homologs in vibrio cholerae directly switches flagellar rotation (2004).

Bacterial Flagellar Motor Switch in Response to CheY-P Regulation and Motor Structural Alterations