NDLI: Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Pereira-Filho, Rose Nely Batista, Fellipe Santos Ribeiro, Danielle Rodrigues Melo, Genecy Calado de Reis, Francisco Prado Melo, Allan Ulisses Carvalho de Gomes, Margarete Zanardo Cardoso, Juliana Cordeiro Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Abstract	The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (treated with water and tumor induction), GP10 (treated with 10 mg/kg HEGP and tumor induction), GP50 (treated with 50 mg/kg HEGP and tumor induction) and GP100 (treated with 100 mg/kg HEGP and tumor induction). Cancer induction was performed in the back of the mice by topical application of DMBA. After 16 weeks, mice were euthanized and their backs were submitted to post-mortem histological analysis. The mean number of lesions developed in TUM (4.14±0.89) was significantly higher than in GP10 (2.05±1.02), GP50 (1.8±1.92) and GP100 (2.5±1.73) (p<0.05). The tumors formed in HEGP-treated groups were histologically more differentiated, but only in PV100 in situ lesions were evidenced. Infiltration of anatomical noble structures was less frequent in HEGP-treated groups (p<0.05). Our data suggest that oral administration of HEGP provided partial inhibition of DMBA-induced dermal carcinogenesis, as well as appeared to modulate the differentiation and infiltrative potential of the carcinomas in rodent model.
Related Links	https://scielo.conicyt.cl/scielo.php?script=sci_abstract&pid=S0717-95022014000200024&lng=en&nrm=iso https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200024&lng=en&nrm=iso
Starting Page	522
Ending Page	530
Page Count	9
File Format	PDF
ISSN	07179502
DOI	10.4067/S0717-95022014000200024
Journal	International Journal of Morphology
Issue Number	2
Volume Number	32
Language	English
Publisher	Sociedad Chilena de Anatomía
Publisher Date	2014-06-01
Publisher Institution	University Tiradentes Science and Technology Institute University Tiradentes School of Dentistry
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Propolis Skin cancer DMBA Propoleos Cáncer de piel
Alternative Title	Efecto Quimiopreventivo del Propóleos Verde Brasileño sobre la Carcinogénesis Cutánea en el Modelo Murino Experimental
Content Type	Text
Resource Type	Article
Subject	Anatomy

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