NDLI: Astrocytic and microglial response and histopathological changes in the brain of horses with experimental chronic Trypanosoma evansi infection

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Lemos, Karen Regina Marques, Luiz Carlos Aquino, Lucia Padilha Cury Thomaz Alessi, Antonio Carlos Zacarias, Rosangela Zacarias
Abstract	This study aimed to characterize astrocytic and microglial response in the central nervous system (CNS) of equines experimentally infected with T. evansi. The experimental group comprised males and females with various degrees of crossbreeding, ages between four and seven years. The animals were inoculated intravenously with 10(6) trypomastigotes of T. evansi originally isolated from a naturally infected dog. All equines inoculated with T. evansi were observed until they presented symptoms of CNS disturbance, characterized by motor incoordination of the pelvic limbs, which occurred 67 days after inoculation (DAI) and 124 DAI. The animals in the control group did not present any clinical symptom and were observed up to the 125th DAI. For this purpose the HE histochemical stain and the avidin biotin peroxidase method was used. Lesions in the CNS of experimentally infected horses were those of a wide spread non suppurative meningoencephalomyelitis.The severity of lesions varied in different parts of the nervous system, reflecting an irregular distribution of inflammatory vascular changes. The infiltration of mononuclear cells was associated with anisomorphic gliosis and reactive microglia was identified. The intensity of the astrocytic response in the CNS of the equines infected by T. evansi characterizes the importance of the performance of these cells in this trypanosomiasis. The characteristic gliosis observed in the animals in this experiment suggests the ability of these cells as mediators of immune response. The parasite, T. evansi, was not identified in the nervous tissues.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46652008000400011&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000400011&lng=en&nrm=iso
Starting Page	243
Ending Page	249
Page Count	7
File Format	PDF
ISSN	00364665
DOI	10.1590/S0036-46652008000400011
Journal	Revista do Instituto de Medicina Tropical de São Paulo
Issue Number	4
Volume Number	50
Language	English
Publisher Date	2008-08-01
Publisher Institution	UNICENTRO Departamento de Medicina Veterinária UNESP FCAV Departamento de Clínica Médica e Cirurgia UNESP FCAV Departamento de Patologia veterinária Instituto de Medicina Tropical
Publisher Place	Brasil
Access Restriction	Open
Subject Keyword	Trypanosoma evansi Trypanosomiasis MHC type II Astrocytes Microglia
Alternative Title	Resposta astrocítica e microglial e alterações histopatológicas no sistema nervoso central de eqüinos infectados cronicamente com Trypanosoma evansi
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases

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