NDLI: Presence of Circulating Levels of Interferon-g, Interleukin-10 and Tumor Necrosis Factor-a in Patients with Visceral Leishmaniasis

Content Provider	Scientific Electronic Library Online (SciELO)
Author	MEDEIROS, Iara Marques de CASTELO, Adauto SALOMÃO, Reinaldo
Abstract	Experimental murine L. major infection is characterized by the expansion of distinct CD4+ T cell subsets. The Th1 response is related to production of IFN-g and resolution of infection, whereas Th-2 response with production of IL-4 and IL-10 and dissemination of infection. The objective of this study was to measure the circulating levels of IFN-g, IL-10 and TNF-a in patients with visceral leishmaniasis (VL) before, during and at the end of therapy and to examine the association between cytokine levels and activity of VL. Fifteen patients with VL were evaluated. The cytokine determinations were done by using the enzyme-linked immunoassay (ELISA) before, during and at the end of therapy. At baseline, we detected circulating levels of IFN-g in 13 of 15 patients (median = 60 pg/ml); IL-10 in 14 of 15 patients (median = 141.4 pg/ml); and TNF-a in 13 of 14 patients (median = 38.9 pg/ml). As patients improved, following antimonial therapy, circulating levels of IL-10 showed an exponential decay (y = 82.34 e 0,10367x, r = 0.659; p < 0.001). IFN-g was no longer detected after 7/14 days of therapy. On the other hand, circulating levels of TNF-a had a less pronounced decay with time on therapy, remaining detectable in most patients during the first seven days of therapy (y = 36.99-0.933x, r = 0.31; p = 0.05). Part of the expression of a successful response to therapy may, therefore, include reduction in secretion of inflammatory as well as suppressive cytokines. Since IL-10 and IFN-g are both detected prior to therapy, the recognized cellular immune depression seen in these patients may be due to biological predominance of IL-10 (type 2 cytokine), rather than lack of IFN-g (type 1 cytokine) production.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0036-46651998000100007&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000100007&lng=en&nrm=iso
Starting Page	31
Ending Page	34
Page Count	4
File Format	PDF
ISSN	00364665
DOI	10.1590/S0036-46651998000100007
Journal	Revista do Instituto de Medicina Tropical de São Paulo
Issue Number	1
Volume Number	40
Language	English
Publisher Date	1998-01-01
Publisher Institution	Universidade Federal de São Paulo Instituto de Medicina Tropical
Access Restriction	Open
Subject Keyword	Cytokines IL-10 Visceral Leishmaniasis (Kala-Azar
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases

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