NDLI: Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Menezes, Hunaldo Lima de Jucá, Mário Jorge Gomes, Edmundo Guilherme de A. Nunes, Benício L. Bulhões B. P. Costa, Henrique Oliveira Matos, Delcio
Abstract	CONTEXT: Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer OBJECTIVE: To analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. METHOD: Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", São Paulo, SP, Brazil, between 2002 and 2005. Thin sections (4 µm) were subjected to immunohistochemical reactions, and immunoexpression staining scores were obtained. The scores were correlated with the degree of cell differentiation, staging, disease-free interval, recurrence, survival and specific mortality. The study variables were analyzed using the chi-square and Kaplan-Meier tests to investigate associations with the markers. The significance of the differences between the curves of the disease-free interval and survival was analyzed using the Logrank and Wilcoxon tests. RESULTS: The immunohistochemical expression of p53 was positive in 70 tumors (85.4%) and negative in 12 (14.6%). The expression of bcl-2 was positive in 26 (31.7%) and negative in 56 (68.3%). The expression of Ki-67 was positive in 62 (75.6%) and negative in 20 (24.4%). There was no statistically significant correlation between the expressions of these markers separately or in conjunction, in relation to the degree of cell differentiation, staging, disease-free interval, survival and specific mortality. In relation to recurrence, there was a statistically significant correlation with positive expression of Ki-67 (P = 0.035). CONCLUSION: The immunohistochemical expression of Ki-67 in colorectal cancer is associated with recurrence of this disease.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-28032010000200005&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032010000200005&lng=en&nrm=iso
Starting Page	141
Ending Page	147
Page Count	7
File Format	PDF
ISSN	00042803
DOI	10.1590/S0004-28032010000200005
Journal	Arquivos de Gastroenterologia
Issue Number	2
Volume Number	47
Language	English
Publisher Date	2010-06-01
Publisher Institution	Federal University of São Paulo Escola Paulista de Medicina Postgraduate Program on Surgical Gastroenterology Federal University of Alagoas School of Medicine Discipline of Coloproctology UFAL FM Department of Surgery State University of Health Sciences of Alagoas Department of Pathology UNIFESP EPM Discipline of Surgical Gastroenterology Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
Publisher Place	Brazil
Access Restriction	Open
Subject Keyword	Colorectal neoplasms Adenocarcinoma Immunohistochemistry Tumor suppressor protein p53 Proto-oncogene proteins c-bcl-2 Bcl-2 homologous antagonist-killer protein Neoplasias colorretais Imunoistoquímica Proteína proto-oncogênicas c-bcl-2 Proteína killer-antagonista homóloga a bcl-2
Alternative Title	Análise das expressões imunoistoquímicas da p53, bcl-2 e Ki-67 no adenocarcinoma colorretal e suas correlações com os fatores prognósticos
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cell proliferation and apoptosis in gastric cancer and intestinal metaplasia

Bcl-2 expression in rectal cancer

Adenocarcinoma of the esophagogastric junction: relationship between clinicopathological data and p53, cyclin D1 and Bcl-2 immunoexpressions

p53 and Ki-67 in Barrett's carcinoma: is there any value to predict recurrence after circumferential endoscopic mucosal resection?

Bi-transgenic Mice Reveal that $K-ras^{Val12}$ Augments a p53-independent Apoptosis When Small Intestinal Villus Enterocytes Reenter the Cell Cycle

Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer.

APC protein immunoexpression in colorectal adenoma and adenocarcinoma

Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma.

PUMA mediates the apoptotic response to p53 in colorectal cancer cells.

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Similar Documents

Cell proliferation and apoptosis in gastric cancer and intestinal metaplasia

Bcl-2 expression in rectal cancer

Adenocarcinoma of the esophagogastric junction: relationship between clinicopathological data and p53, cyclin D1 and Bcl-2 immunoexpressions

p53 and Ki-67 in Barrett's carcinoma: is there any value to predict recurrence after circumferential endoscopic mucosal resection?

Bi-transgenic Mice Reveal that $K-ras^{Val12}$ Augments a p53-independent Apoptosis When Small Intestinal Villus Enterocytes Reenter the Cell Cycle

Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer.

APC protein immunoexpression in colorectal adenoma and adenocarcinoma

Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma.

PUMA mediates the apoptotic response to p53 in colorectal cancer cells.

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors