NDLI: Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis,

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Baldin Júnior, Antônio Telles, José Ederaldo Queiroz Bonardi, Renato de Araújo Amarante, Heda Maria Barska dos Santos Baldin, Rosimeri Kuhl Svoboda
Abstract	Background: The association between ulcerative colitis and adenocarcinoma determined strategies for patient follow-up and early detection of dysplastic and neoplastic lesions. Aims: To analyze the incidence of dysplasia in patients with ulcerative colitis, comparing clinical data of patients with and without dysplasia and check immunohistochemical expression of p53 protein in dysplasias. Materials and methods: We analyzed biopsy samples and clinical data of 124 patients with ulcerative colitis at Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Results: Dysplasia incidence was low (9.67%) and all cases with low-grade dysplasia. Patients clinical data comparison with and without dysplasia did not show significant statistical differences with regard to the race, age at the start of the disease, age at last biopsy, duration and anatomic extent of ulcerative colitis. Significant difference was found between males and females with predominance of males (58.34%) for dysplasia. Seventeenth biopsy samples of 12 patients with dysplasia, 5 (29.4%) were p53 positive. Conclusions: From these results it is concluded that the incidence of dysplasia was low, higher in males and there was positivity of p53 protein in dysplasia.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S2237-93632014000300136&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632014000300136&lng=en&nrm=iso
Starting Page	136
Ending Page	140
Page Count	5
File Format	PDF
ISSN	22379363
DOI	10.1016/j.jcol.2014.02.009
Journal	Journal of Coloproctology (Rio de Janeiro)
Issue Number	3
Volume Number	34
Language	English
Publisher	Sociedade Brasileira de Coloproctologia
Publisher Date	2014-09-01
Access Restriction	Open
Subject Keyword	Ulcerative rectocolitis Dysplasia Protein p53 Retocolite ulcerative Displasia Proteína p53
Alternative Title	Estudo clínico-patológico e da expressão da proteína p53 nas displasias associadas à retocolite ulcerativa
Content Type	Text
Resource Type	Article
Subject	Gastroenterology

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